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Effects of Short-term Swimming Exercise Training on Lactate Levels, MCT 1 Contents and Circulating Ketone Bodies in Rat Skeletal Muscle |
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Ho-Seong Lee |
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Dankook University |
Correspondence:
Ho-Seong Lee,
Email: hoseh28@dankook.ac.kr
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Received: 5 September 2013 • Accepted: 19 October 2013 |
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| Abstract |
INTRODUCTION
The purpose of this study was to examine the effect of short-term swimming exercise training on lactate levels, MCT 1 contents and circulating ketone bodies in rat skeletal muscle.
METHOD
Male Sprague-Dawley rats (N=32) were performed swimming exercise training for 60 minute/day and 7 days/week, for 3 weeks. Lactate in rat skeletal muscle was measured immediately after (IA, n=8), and MCT 1 protein in soleus muscle, extensor digitorum longus muscle and liver were measured before exercise (pre, n=8), after 7 days (7D, n=8) and 21 days (21D, n=8). In Glucocorticoid administration, Male Sprague-Dawley rats (N=14) were assigned to administration group (AG, n=7) and control group (CON, n=7). Administration group was subcutaneous injected prednisolone acetate (2mg/kg) and normal saline in control group, for 4 days, and than MCT 1 protein and blood ketone body were measured after injections.
RESULT
Lactate concentration in soleus muscle and extensor digitorum longus muscle were significantly increased immediately after of swimming exercise training compared with before exercise (p<.005, p<.008 respectively). MCT 1 protein in soleus muscle, extensor digitorum longus muscle were significantly increased after both 7 and 21 days of swimming exercise training compared with before exercise (p<.032, p<.005; p<.037, p<.028 respectively), and MCT 1 protein in liver was significantly increased after 21 days of swimming exercise training (p<.037). In Glucocorticoid administration, MCT 1 protein in liver and blood ketone body concentration were significantly increased in the administration group than in the control group (p<.027, p<.021 respectively).
CONCLUSION
These results suggest that product of intracellular endogenous monocarboxylic and proton induces MCT 1 in the skeletal muscle and liver during short-term swimming exercise training.
논문투고일 : 2013. 9. 5
1차 수정일 : 2013. 9. 27
2차 수정일 : 2013. 10. 11
게재확정일 : 2013. 10. 19
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| Keywords:
swimming exercise training, skeletal muscle, lactate, monocarboxylate transporter 1, ketone body |
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