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Asian J Kinesiol > Volume 15(2); 2013 > Article
The Official Journal of the Korean Academy of Kinesiology 2013;15(2):61-67.
DOI: https://doi.org/10.15758/jkak.2013.15.2.61    Published online April 30, 2013.
Understanding the Mechanism of an Exercise-induced Opioid Effect in Reducing Neuropathic Pain
Junga Lee, Deog-Jo Jung
Seoul National University
Seowon University
Correspondence:  Deog-Jo Jung,
Email: jdj1116@hanmail.net
Received: 2 October 2012   • Accepted: 20 April 2013

Prior studies have increasingly indicated that chronic diseases might be causing neuropathic pain. As many patients with chronic diseases do indicate neuropathic pain, there is a growing interest in finding a treatment for this pain. One beneficial treatment might be the exercise-induced opioid effect that could help to reduce this neuropathic pain. Thus, the purpose of this study is to explain the possible mechanism related to reducing neuropathic pain as a result of the exercise-induced opioid release.
This study reviews prior research on neuropathic pain and the exercise effect to explain the possible mechanism relating to an exercise-induced opioid effect that reduces neuropathic pain.
The possible mechanisms relating to the exercise-induced opioid effect include: 1) an exercise-induced analgesic effect, and 2) exercise-induced opioid and neurotropic factors. The effect of exercise-induced opioids was proven by indications of opioid with drawal and by increasing opioid to lerance. Additionally, increasing the neurotropic factors would help increase the analgesic effect of opioids and serotonin.
The exercise-induced opioid effect would reduce neuropathic pain, indicate opioid withdrawal, increase opioid tolerance, and identify neurotropic factors. Future research should examine the effects of exercise intensity and duration to better understand the treatment mechanism, which ultimately will help to prevent and treat chronic pain.
Keywords: Exercise, Neuropathic pain, Exercise-induced opioid, Neurotrophic factors
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